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| Registros recuperados: 12 | |
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| Brincas,Heloisa Magagnin; Augusto,Danillo G.; Mathias,Carolina; Cavalli,Iglenir João; Lima,Rubens Silveira de; Kuroda,Flávia; Urban,Cícero de Andrade; Gradia,Daniela Fiori; de Oliveira,Jaqueline; de Almeida,Rodrigo Coutinho; Ribeiro,Enilze Maria de Souza Fonseca. |
| Abstract MicroRNAs (miRNAs) play an essential role in gene expression and affect the development of tumours, including breast cancer (BC). Polymorphisms in miRNA genes can affect the interaction of miRNAs with their target messenger RNA by interfering, creating or disrupting target sites. The single nucleotide polymorphism (SNP) rs2910164, located in the seed region of miR146a, was shown to be associated with BC among different populations. In the present study, we investigated whether rs2910164 is associated with BC in 326 patients and 411 controls from a Brazilian population of predominantly European ancestry. The presence of the allele rs2910164*C was associated with an increased risk of BC (OR=1.4, 95% CI=1.03-1.85, p = 0.03). We also analysed publicly... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: MiRNA polymorphism; MiR146a; Rs2910164; Breast cancer; Case-control study. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000500103 |
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| Liao,Xiaoyang; Yang,Zhiyi; Peng,Daqing; Dai,Hua; Lei,Yi; Zhao,Qian; Han,Yanbing; Wang,Weiwen. |
| The association between T174M polymorphism of angiotensinogen gene and essential hypertension risk remains controversial. We herein performed a meta-analysis to achieve a reliable estimation of their relationship. All the studies published up to May 2013 on the association between T174M polymorphism and essential hypertension risk were identified by searching the electronic repositories PubMed, MEDLINE and EMBASE, Springer, Elsevier Science Direct, Cochrane Library and Google Scholar. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated. Ultimately, nine eligible studies, including 2188 essential hypertension cases and 2459 controls, were enrolled in this meta-analysis. No significant associations were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Essential hypertension; Case-control study; T174M; Polymorphism; Meta-analysis. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000400001 |
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| Brunoni,A.R.; Lotufo,P.A.; Sabbag,C.; Goulart,A.C.; Santos,I.S.; Benseñor,I.M.. |
| Brain-derived neurotrophic factor (BDNF) is associated with neuroplasticity and synaptic strength, and is decreased in conditions associated with chronic stress. Nevertheless, BDNF has not yet been investigated in psoriasis, a chronic inflammatory systemic disease that is exacerbated by stress. Therefore, our aim was to determine BDNF plasma levels in psoriasis patients and healthy controls. Adult patients (n=94) presenting with psoriasis for at least 1 year were enrolled, and age- and gender-matched with healthy controls (n=307) from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Participants had neither a previous history of coronary artery disease nor current episode of major depression. BDNF plasma levels were determined using the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Brain derived neurotrophic factor; Psoriasis; Neurotrophins; Psychological stress; Case-control study. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000800711 |
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| Lupo, Coralie; Osta-amigo, Axel; Mandard, Yann-vari; Peroz, Carole; Renault, Tristan. |
| Farmers’ vigilance is essential for the detection of epidemics, including potential emerging diseases, in marine shellfish. A field study was conducted to investigate oyster farmers’ reporting practices and behaviour, and to identify factors influencing the reporting process of oyster mortality, with the ultimate aim of improving early detection of unexplained oyster mortality outbreaks. A retrospective case-control study of oyster farmers from Charente-Maritime (France) was designed, based on interviews with 27 non-reporting and 89 reporting farmers, further split into 40 formerly-reporting and 49 currently-reporting farmers. Information about farmer and farm characteristics, farming practices, farm health history and related financial compensation on... |
| Tipo: Text |
Palavras-chave: Case-control study; Ordinal logistic regression; Surveillance; Notification; Shellfish diseases. |
| Ano: 2014 |
URL: http://archimer.ifremer.fr/doc/00190/30132/28594.pdf |
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| Tamez-Torres,Karla Maria; Torres-Gonzalez,Pedro; Cervera-Hernandez,Miguel E.; Chavez-Mazari,Barbara; Barrientos-Flores,Corazon de Jesus; Bobadilla-del-Valle,Miriam; Ponce-de-Leon,Alfredo; Sifuentes-Osornio,Jose. |
| ABSTRACT Objectives: To determine the factors associated with Mycobacterium tuberculosis complex-positive blood culture. Methods: Case-control study. Sociodemographic, clinical and laboratory data were collected from 2000 to 2015. Results: We reviewed medical records of 533 patients with culture-proven tuberculosis, of whom 27.2% (145/533) had blood culture available. Patients with mycobacteremia presented more frequently with abdominal tuberculosis, body mass index <18 kg/m2, and had lower hemoglobin and albumin levels. No differences were observed regarding HIV status. Conclusions: Few studies have reported on the characteristics associated with Mycobacterium tuberculosis complex bacteremia, especially among Human Immunodeficiency Virus-negative... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mycobacterium tuberculosis; Human immunodeficiency virus; Bloodstream infection; Mycobacteremia; Case-control study. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500387 |
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| Zidane, Monia; Ren, Yen; Xhaard, Constance; Leufroy, Axelle; Côte, Suzanne; Dewailly, Eric; Noël, Laurent; Guérin, Thierry; Bouisset, Patrick; Bernagout, Solène; Paaoafaite, John; Iltis, Jacques; Taquet, Marc; Suhas, Eric; Rachédi, Frédérique; Boissin, Jean Louis; Sebbag, Joseph; Shan, Larrys; Bost-bezeaud, Frédérique; Petitdidier, Patrice; Rubino, Carole; Gardon, Jacques; De Vathaire, Florent. |
| Background: In French Polynesia, thyroid cancer mortality and incidence is reported to be the highest in the world. Excessive levels of non-essential trace elements (nETE) in the body are associated with several types of cancer. Objective: The present study aims to provide quantitative information on food contamination by mercury (Hg), lead (Pb), arsenic (As) and cadmium (Cd) in French Polynesia and its potential correlation with measurements performed in fingernails of Polynesians, and then to investigate the potential association between these nETE and different thyroid cancer risks. Methods: The study population included 229 interviewed cases and 373 interviewed controls We performed a descriptive analysis of Polynesian food and examined the association... |
| Tipo: Text |
Palavras-chave: Thyroid cancer; NETE; Diet; Fingernail; Case-control study. |
| Ano: 2019 |
URL: https://archimer.ifremer.fr/doc/00660/77190/78617.pdf |
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| Mendizabal,Maria de Fátima Magalhães Acioly; Bezerra,Phelipe Cunha; Guedes,Diego Lins; Cabral,Diogo Buarque Cordeiro; Miranda-Filho,Demócrito de Barros. |
| This was a case-control study to identify prognostic indicators of bacterial meningitis in a reference hospital in Pernambuco/Brazil. The data were collected from charts of 294 patients with bacterial meningitis between January 2000 and December 2004. Variables were grouped in biological, clinical, laboratory and etiologic agent/treatment. Variables selected in each step were grouped and adjusted for age. Two models were created: one containing clinical variables (clinical model) and other containing laboratory variables (laboratory model). In the clinical model the variables associated with death due to bacterial meningitis were dyspnea (p = 0.006), evidence of shock (p = 0.051), evidence of altered mental state (p = 0.000), absence of headache (p =... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bacterial meningitis; Prognostic indicators; Case-control study. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500005 |
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| de-Almada,B.V.P.; de-Almeida,L.D.; Camporez,D.; de-Moraes,M.V.D.; Morelato,R.L.; Perrone,A.M.S.; Belcavello,L.; Louro,I.D.; de-Paula,F.. |
| Although several alleles of susceptibility to Alzheimer’s disease (AD) have been studied in the last decades, few polymorphisms have been considered as risk factors for the disease. Among them, the APOE-e4 allele appears to be the major genetic risk factor for the onset of the disease. However, it is important to confirm the potential susceptibility of these genetic variants in different populations in order to establish a genetic profile for the disease in specific communities. This study analyzed the APOE polymorphisms regarding susceptibility to AD in a sample of 264 individuals (primarily Caucasians; 82 cases and 182 controls) in the population from Vitória, ES, Brazil, by PCR restriction fragment length polymorphism (PCR-RFLP) methods. The patients... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Alzheimer’s disease; APOE-e3 allele; APOE-e4 allele; Brazilian population; Case-control study. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000100002 |
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| Cimponeriu,Danut; Apostol,Pompilia; Radu,Irina; Craciun,Anne Marie; Serafinceanu,Cristian; Toma,Mihai; Panaite,Cristian; Cheta,Dan. |
| The insulin -23Hph and IGF2 Apa polymorphisms were genotyped in Romanian patients with T1DM (n = 204), T2DM (n = 215) or obesity (n = 200) and normoponderal healthy subjects (n = 750). The genotypes of both polymorphisms were distributed in concordance with Hardy-Weinberg equilibrium in all groups. The -23Hph AA genotype increased the risk for T1DM (OR: 3.22, 95%CI: 2.09-4.98, p < 0,0001), especially in patients without macroalbuminuria (OR: 4.32, 95%CI: 2.54-7.45, p < 0,0001). No other significant association between the alleles or genotypes of insulin -23Hph and IGF2 Apa and diabetes or obesity was identified. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Insulin -23Hph; Insulin-like growth factor 2 Apa; Diabetes; Obesity; Case-control study. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000400003 |
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| Yang,Haoyu; Li,Jin; Jiang,Lifeng; Jiang,Xijia; Zhou,Xindie; Xu,Nanwei. |
| The autoimmune regulator (AIRE), a transcriptional regulator expressed in medullary thymic epithelial cells, plays an important role in thymocyte education and negative selection. Several citations studying the association between the rs878081 exon polymorphism of the AIRE gene and the risk of rheumatoid arthritis (RA) in different populations have yielded conflicting findings. Thus, this case-control study involving 300 RA cases and 300 controls was aimed to identify whether such association existed in a Chinese Han population from East China. The rs878081 polymorphism of the AIRE gene was genotyped. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using the chi-squared test, genetic model analysis, and stratification analysis. Genetic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: AIRE; Single-nucleotide polymorphism; Rheumatoid arthritis; Case-control study. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200612 |
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| Registros recuperados: 12 | |
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